Cinnamoyl Chloride → (E)-1-(2-pyridyl)-2-styryl-5-trifluoromethyl-1H-benzimidazole

HRID 382552Notes

Reaction equation

HRID 382552 reaction equation
[NH2:1][C:2]1[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:11][C:3]=1[NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1.[C:19](Cl)(=O)/[CH:20]=[CH:21]/[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.N1C=CC=CC=1N1C2C=CC=CC=2N=C1/C=C/C1C=CC=CC=1>>[N:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[N:4]1[C:3]2[CH:11]=[CH:12][C:13]([C:15]([F:18])([F:16])[F:17])=[CH:14][C:2]=2[N:1]=[C:19]1/[CH:20]=[CH:21]/[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

4

Reactant 3

HCID 5354261Cinnamoyl ChlorideHCID 9796241(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazoleHCID 227367071,2-Benzenediamine, N1-2-pyridinyl-4-(trifluoromethyl)-

Product 1

HCID 22736704(E)-1-(2-pyridyl)-2-styryl-5-trifluoromethyl-1H-benzimidazole

Procedure

The titled compound was prepared from 2-amino-N-(2-pyridyl)-4-trifluoromethylaniline and (E)-cinnamoyl chloride according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A).

Sources & evidence

ORD record
ord-f81d4b529a7d4793aef5f1ecaa676a38
Source dataset
uspto-grants-2001_10
Patent number
US06310079B1

Reaction notes

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