Oxalic Acid → HCID 22736741, compound

HRID 382565Notes

Reaction equation

HRID 382565 reaction equation
C[O:2][C:3]1[CH:25]=[CH:24][C:6]2[N:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)[C:8](/[CH:10]=[CH:11]/[C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:9][C:5]=2[CH:4]=1.OC1C=C(C=CC=1)C=CC1(/C=C/C2C=CC=CC=2)N(C2C=CC=CN=2)C2C=CC(C(F)(F)F)=CC=2N1.C(O)(=O)C(O)=O>C(OCC)(=O)C>[OH:2][C:3]1[CH:25]=[CH:24][C:6]2[N:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)[C:8](/[CH:10]=[CH:11]/[C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:9][C:5]=2[CH:4]=1

Participants

5

Reactant 3

HCID 971Oxalic AcidHCID 22736664HCID 22736664, compoundHCID 86594300HCID 86594300, compound

Product 1

HCID 22736741HCID 22736741, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Free base of the titled compound was prepared from (E)-5-methoxy-1-(2-pyridyl)-2-styryl-1H-benzimidazole according to the preparation of (E)-2-(3-Hydroxystyryl)-1-(2-pyridyl)-2-styryl-5-trifluoromethyl-1H-benzimidazole (Example 32). The free base and oxalic acid were dissolved into ethyl acetate. Concentration and recrystallization from ethyl acetate/n-hexane yielded the titled compound.

Workup

  1. concentrationConcentration and recrystallization from ethyl acetate/n-hexane

Sources & evidence

ORD record
ord-e57ac665456541509d795e76024dea71
Source dataset
uspto-grants-2001_10
Patent number
US06310079B1

Reaction notes

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