反应详情

To the product of step b) (0.34 g) in DCM (5 ml) was added Hunigs base (1 ml) followed by methanesulfonyl chloride (0.46 ml) and the reaction stirred at room temperature for 2 h followed by heating at 45° C. for 2 h. After cooling to 0° C. the bulk of the volatiles were removed in vacuo. Diethyl ether and water were added and the organic layer separated.

1. temperatureby heating at 45° C. for 2 h
2. temperatureAfter cooling to 0° C. the bulk of the volatiles
3. customwere removed in vacuo
4. additionDiethyl ether and water were added
5. customthe organic layer separated