1-(5-Chloro-2-methoxyphenyl)piperazine--hydrogen chloride (1/1) → 4-Chloro-2-(1-piperazinyl)phenol

Participants

Reaction Steps

1-(5-chloro-2-methoxyphenyl)-piperazine hydrochloride (8 g) was heated in a solution of 48% aqueous HBr (200 ml) and the mixture was heated at reflux for 99 hours. The reaction mixture was concentrated in vacuo, the sub-title compound was used directly without any further purification.

Provenance & Evidence