1-(5-Chloro-2-methoxyphenyl)piperazine--hydrogen chloride (1/1) → 4-Chloro-2-(1-piperazinyl)phenol

HRID 38262Notes

Reaction equation

HRID 38262 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([O:15]C)=[C:7]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:8]=1>Br>[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([OH:15])=[C:7]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:8]=1

Participants

3

Reactant 1

HCID 242064191-(5-Chloro-2-methoxyphenyl)piperazine--hydrogen chloride (1/1)

Product 1

HCID 234478814-Chloro-2-(1-piperazinyl)phenol

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

1-(5-chloro-2-methoxyphenyl)-piperazine hydrochloride (8 g) was heated in a solution of 48% aqueous HBr (200 ml) and the mixture was heated at reflux for 99 hours. The reaction mixture was concentrated in vacuo, the sub-title compound was used directly without any further purification.

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 99 hours
  3. concentrationThe reaction mixture was concentrated in vacuo
  4. customthe sub-title compound was used directly without any further purification

Sources & evidence

ORD record
ord-5bfe1826ff82486f92b2608ca27fb722
Source dataset
uspto-grants-2013_09
Patent number
US08524715B2

Reaction notes

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