Hydracrylonitrile → HCID 23004047, compound

HRID 382685Notes

Reaction equation

HRID 382685 reaction equation
[O:1]=[C:2]([CH2:9][CH2:10][CH3:11])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].OCC[C:15]#[N:16]>>[C:15]([CH2:8][CH2:7][O:6][C:4](=[O:5])[CH2:3][C:2](=[O:1])[CH2:9][CH2:10][CH3:11])#[N:16]

Participants

3

Reactant 2

HCID 8011HydracrylonitrileHCID 238498Ethyl 3-oxohexanoate

Product 1

HCID 23004047HCID 23004047, compound

Conditions

Temperature
192.5 °C

Procedure

A mixture of ethyl 3-oxohexanoate (33.7 mmol) and 3-hydroxypropionitrile (28.1 mmol) were placed in a round bottom flask (magnetically stirred) equipped with a short distillation path. The resulting mixture was gradually heated to 180-205° C. in an oil bath. The distillate was collected. The mixture was then cooled to room temperature and the residue was distilled under reduced pressure to give 2-cyanoethyl -3-oxohexanoate.

Workup

  1. customwere placed in a round bottom flask
  2. customequipped with a short distillation path
  3. distillationThe distillate was collected
  4. temperatureThe mixture was then cooled to room temperature
  5. distillationthe residue was distilled under reduced pressure

Sources & evidence

ORD record
ord-9ca607c7d1f7412e96269cdfafd9d31f
Source dataset
uspto-grants-2001_10
Patent number
US06310076B1

Reaction notes

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