Ammonium Chloride → 1-(4'-fluorophenyl)-1,3-dihydroisobenzofuran-5-ylmethanol

Temperature

-40 °C

An about 93:7 mixture (34.7 g) of 2,4-bis(1′-ethoxyethoxymethyl)bromobenzene and 2,6-bis(1′-ethoxyethoxymethyl)bromobenzene was dissolved in dehydrated tetrahydrofuran (250 ml) under a nitrogen atmosphere and cooled to −40° C. Thereto was added dropwise a hexane solution (1.57 mol/L, 64.3 ml) of n-butyllithium at a temperature of from −40° C. to −30° C. The mixture was heated to −20° C. and thereto was added dropwise p-fluorobenzaldehyde (12.5 g). The mixture was allowed to warm to 15° C. over 1 hr. The reaction mixture was poured into 20% aqueous ammonium chloride solution (200 ml) and the organic layer was separated. The aqueous layer was extracted with toluene (200 ml). The combined organic layer was washed twice with 20% brine (250 ml) and the solvent was evaporated. To the residue (38.5 g) was added 60% phosphoric acid (300 g) and the resulting solution was stirred at 80-85° C., 9.31-13.3 kPa (70-100 Torr) for 2 hr with heating and cooled to 10° C. The resulting crystals were collected by filtration, washed thoroughly with ethanol and dried to give 1-(4′-fluorophenyl)-1,3-dihydroisobenzofuran-5-ylmethanol (20.8 g, 88.7%) as fine yellow crystals.

1. temperatureThe mixture was heated to −20° C.
2. temperatureto warm to 15° C. over 1 hr
3. customthe organic layer was separated
4. extractionThe aqueous layer was extracted with toluene (200 ml)
5. washThe combined organic layer was washed twice with 20% brine (250 ml)
6. customthe solvent was evaporated
7. additionTo the residue (38.5 g) was added 60% phosphoric acid (300 g)
8. temperature9.31-13.3 kPa (70-100 Torr) for 2 hr with heating
9. temperaturecooled to 10° C
10. filtrationThe resulting crystals were collected by filtration
11. washwashed thoroughly with ethanol
12. customdried

ORD record

ord-97a4be2f11a841ebbffca389d572792b

Source dataset

uspto-grants-2001_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06310222B1