反应详情

温度

170 °C

8-Hydroxyquinaldine (5.0 g) and potassium carbonate (13.02 g) are mixed together in a stainless steel bomb and heated to 170° C. under 800 p.s.i. CO2 for 6 days. The reaction is then cooled and the resulting solid is partitioned between EtOAc and water. The organic layer is extracted with water (3×). The combined aqueous layers are washed with EtOAc (3×). The aqueous layer is then acidified to pH 4.5 with conc. HCl. The resulting solid is collected, dried and recrystallized from i-PrOH to yield 1.86 g of the title compound as a gold solid.

1. temperatureThe reaction is then cooled
2. customthe resulting solid is partitioned between EtOAc and water
3. extractionThe organic layer is extracted with water (3×)
4. washThe combined aqueous layers are washed with EtOAc (3×)
5. customThe resulting solid is collected
6. customdried
7. customrecrystallized from i-PrOH