HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazomethane → HCID 54504095, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | HCID 53907459 | HCID 53907459 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 54504095 | HCID 54504095 | — |
Reaction Steps
The 3-[3,5-bis(trifluoromethyl)phenyl]-propynoic acid was dissolved in a mixture of THF and ether and treated with diazomethane until all acid was methylated. All solvent was removed and the resulting oil was purified by chromatography (10% ether/hexane) to give 30.5 g of 3-[3,5-bis(trifluoromethyl)phenyl]-propynoic acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310247B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-ef244c4469cb426aa697179901720951 |
| Source note | uspto-grants-2001_10 |