Diazomethane → HCID 54504095, compound

HRID 382898Notes

Reaction equation

HRID 382898 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:4]=[C:5]([C:13]#[C:14][C:15]([OH:17])=[O:16])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[N+](=[CH2:22])=[N-]>C1COCC1.CCOCC>[CH3:22][O:16][C:15](=[O:17])[C:14]#[C:13][C:5]1[CH:4]=[C:3]([C:2]([F:18])([F:19])[F:1])[CH:8]=[C:7]([C:9]([F:11])([F:12])[F:10])[CH:6]=1

Participants

5

Reactant 2

HCID 9550DiazomethaneHCID 53907459HCID 53907459, compound

Product 1

HCID 54504095HCID 54504095, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

The 3-[3,5-bis(trifluoromethyl)phenyl]-propynoic acid was dissolved in a mixture of THF and ether and treated with diazomethane until all acid was methylated. All solvent was removed and the resulting oil was purified by chromatography (10% ether/hexane) to give 30.5 g of 3-[3,5-bis(trifluoromethyl)phenyl]-propynoic acid methyl ester.

Workup

  1. customAll solvent was removed
  2. customthe resulting oil was purified by chromatography (10% ether/hexane)

Sources & evidence

ORD record
ord-ef244c4469cb426aa697179901720951
Source dataset
uspto-grants-2001_10
Patent number
US06310247B1

Reaction notes

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