反应详情

温度

60 °C

A mixed solvent consisting of 24 g of acetic acid, 377 g of t-butanol and 49 g of water was added to the distillate containing the ketene adducts, and 99 g of triethylamine was added dropwise over a period of 2 hours while maintaining the solution temperature at 60° C. Then, the resulting mixture was heated at 60° C. for another 5 hours. After completion of the reaction, analysis by a gas chromatography revealed that peaks due to the ketene adducts disappeared and that hinokitiol was obtained in 66% yield (0.26 mol).

1. additionwas added to the distillate
2. additionwas added dropwise over a period of 2 hours
3. temperatureThen, the resulting mixture was heated at 60° C. for another 5 hours
4. customAfter completion of the reaction, analysis by a gas chromatography