Piconol → HCID 18361791, compound

HRID 382926Notes

Reaction equation

Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]2=[N:12][N:13]=[C:14]([C:15]3[CH:19]=[C:18]([CH2:20][CH3:21])[O:17][N:16]=3)[N:4]2[N:3]=1.[N:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[CH2:28][OH:29]>>[CH2:20]([C:18]1[O:17][N:16]=[C:15]([C:14]2[N:4]3[N:3]=[C:2]([O:29][CH2:28][C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][N:22]=4)[C:11]4[C:6]([C:5]3=[N:12][N:13]=2)=[CH:7][CH:8]=[CH:9][CH:10]=4)[CH:19]=1)[CH3:21]

Participants

Reactant 2

HCID 11474Piconol

HCID 18361721HCID 18361721, compound

Product 1

HCID 18361791HCID 18361791, compound

Procedure

The title-compound was prepared from 6-chloro-3-(5-ethylisoxazol-3-yl)-1,2,4-triazolo[3,4-a]phthalazine and 2-pyridylcarbinol using the procedure given for Example 1, 1H NMR (360 MHz, CDCl3) δ 1.42 (3H, t, J=7.6 Hz, Me), 2.93 (2H, q, J=7.5 Hz, CH2), 5.78 (2H, s, CH2O), 6.83 (1H, s, Ar—H), 7.29 (1H, m, Ar—H), 7.75-7.85 (3H, m, 3 of Ar—H), 7.99 (1H, m, Ar—H), 8.33 (1H, d, J=7.8 Hz, Ar—H), 8.64-8.72 (2H, m, Ar—H); MS (ES+) m/e 373 [MH]+.

Sources & evidence

ORD record: ord-0317fc32aded43cf9fb1a82ca4526cad
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06310203B1

Reaction notes

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