Sodium Hydroxide → HCID 67131966, compound

HRID 38294Notes

Reaction equation

HRID 38294 reaction equation
C([O:3][C:4](=[O:32])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH:13]([CH3:15])[CH3:14])=[CH:9][C:8]=1[CH2:16][N:17]1[CH2:22][CH2:21][N:20]([S:23]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)(=[O:25])=[O:24])[CH2:19][CH2:18]1)C.[OH-].[Na+:34]>C1COCC1.CO>[CH3:15][CH:13]([C:10]1[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]([O-:32])=[O:3])=[C:8]([CH2:16][N:17]2[CH2:18][CH2:19][N:20]([S:23]([C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=3)(=[O:25])=[O:24])[CH2:21][CH2:22]2)[CH:9]=1)[CH3:14].[Na+:34]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 123905854HCID 123905854, compound

Product 1

HCID 67131966HCID 67131966, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of the product from step (e) (113 mg) in NaOH (0.25 ml, 1M), THF (1.5 ml) and MeOH (1 ml) was stirred for 4 h. The solvent was removed in vacuo and the residue triturated with ether to give the title compound (97 mg)

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue triturated with ether

Sources & evidence

ORD record
ord-a796f8d0917943a8b1bfd61a8446946a
Source dataset
uspto-grants-2013_09
Patent number
US08524715B2

Reaction notes

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