2-Pyrazinecarboxylic acid → 6-Chloro-3-(pyrazin-2-yl)-1,2,4-triazolo[3,4-a]phthalazine

HRID 382947Notes

Reaction equation

HRID 382947 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([NH:12][NH2:13])=[N:4][N:3]=1.[N:14]1[CH:19]=[CH:18][N:17]=[CH:16][C:15]=1[C:20](O)=O>>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]2=[N:12][N:13]=[C:20]([C:15]3[CH:16]=[N:17][CH:18]=[CH:19][N:14]=3)[N:4]2[N:3]=1

Participants

3

Reactant 2

HCID 10472-Pyrazinecarboxylic acidHCID 27937521-Chloro-4-hydrazinophthalazine

Product 1

HCID 183618416-Chloro-3-(pyrazin-2-yl)-1,2,4-triazolo[3,4-a]phthalazine

Procedure

The title-compound was prepared from 1-chloro-4-hydrazinophthalazine and pyrazine-2-carboxylic acid as described for Intermediate 1 part c, 1H NMR (250 MHz, CDCl3) δ 7.99 (1H, t, J=7.2 Hz, Ar—H), 8.09 (1H, t, J=8.2 Hz, Ar—H), 8.33 (1H, d, J=6.8 Hz; Ar—H), 8.80 (1H, m, Ar—H), 8.82-8.88 (2H, m, 2 of Ar—H), 9.67 (1H, d, J=1.5 Hz, Ar—H).

Sources & evidence

ORD record
ord-c2a113d12d8e4b8bb50a1540847901e8
Source dataset
uspto-grants-2001_10
Patent number
US06310203B1

Reaction notes

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