Hydrochloric Acid → HCID 22998615, compound

HRID 382965Notes

Reaction equation

HRID 382965 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]2[CH2:7][CH:8]([C:13]([O:15]C)=[O:14])[CH2:9][C:10](=[O:12])[NH:11][C:5]=2[CH:4]=1.[OH-].[Na+].Cl>CO>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]2[CH2:7][CH:8]([C:13]([OH:15])=[O:14])[CH2:9][C:10](=[O:12])[NH:11][C:5]=2[CH:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22998649HCID 22998649, compound

Product 1

HCID 22998615HCID 22998615, compoundYield 89.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of methyl 2,3,4,5-tetrahydro-8-methoxy-2-oxo-1H-1-benzazepine-4-carboxylate (5.035 g) in methanol (60 ml) was added 1 N aqueous sodium hydroxide (40 ml). The reaction mixture was stirred at room temperature for 6.5 hr, made acidic by adding 1 N aqueous hydrochloric acid, and extracted with ethyl acetate. The organic layer was washed with water and saturated aqueous sodium chloride, dried, and concentrated. The resulting crude crystals were washed with diethyl ether to obtain the titled compound (4.253 g).

Workup

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water and saturated aqueous sodium chloride
  3. customdried
  4. concentrationconcentrated
  5. washThe resulting crude crystals were washed with diethyl ether

Sources & evidence

ORD record
ord-d71682473da1495fa7fcd31ad33ca269
Source dataset
uspto-grants-2001_10
Patent number
US06310107B1

Reaction notes

Loading…