Citric Acid → HCID 18361599, compound

HRID 382971Notes

Reaction equation

HRID 382971 reaction equation
[C:1]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:6]=[CH:5][C:4]([CH2:7][O:8][C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[CH2:15][CH:14]([CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])[CH2:13][CH2:12]3)=[CH:3][CH:2]=1.[C:30]([OH:42])(=[O:41])[CH2:31][C:32]([CH2:37][C:38]([OH:40])=[O:39])([C:34]([OH:36])=[O:35])[OH:33]>CO>[C:30]([OH:42])(=[O:41])[CH2:31][C:32]([CH2:37][C:38]([OH:40])=[O:39])([C:34]([OH:36])=[O:35])[OH:33].[C:1]1([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:2]=[CH:3][C:4]([CH2:7][O:8][C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[CH2:15][CH:14]([CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])[CH2:13][CH2:12]3)=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 311Citric AcidHCID 9823548HCID 9823548, compound

Product 1

HCID 18361599HCID 18361599, compoundYield 97.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of (−)-6-(4-biphenylyl)methoxy-2-[2-(N,N-dimethylamino)ethyl]tetralin (1.3 g) in methanol (10 ml) was added a solution of citric acid (0.65 g) in methanol (10 ml) and the resulting precipitated salt was collected by filtration and washed with methanol, ethyl acetate, and diethyl ether to obtain the titled compound (1.9 g).

Workup

  1. customthe resulting precipitated salt
  2. filtrationwas collected by filtration
  3. washwashed with methanol, ethyl acetate, and diethyl ether

Sources & evidence

ORD record
ord-9a75b74f3aad4090b38347173184bd58
Source dataset
uspto-grants-2001_10
Patent number
US06310107B1

Reaction notes

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