Hydrochloric Acid → HCID 18429318, compound

HRID 383012Notes

Reaction equation

HRID 383012 reaction equation
C([O:4][CH:5]([CH3:44])[C:6]([N:8]([CH2:38][CH2:39][O:40]C(=O)C)[C:9]1[C:10]([I:37])=[C:11]([C:17]([I:36])=[C:18]([N:21]([C:28](=[O:35])[CH:29]([O:31]C(=O)C)[CH3:30])[CH2:22][CH2:23][O:24]C(=O)C)[C:19]=1[I:20])CCC([O-])=O)=[O:7])(=O)C.[OH-:45].[Na+].Cl.[CH3:48]O>O>[OH:4][CH:5]([CH3:44])[C:6]([N:8]([CH2:38][CH2:39][OH:40])[C:9]1[C:10]([I:37])=[C:11]([C:17]([I:36])=[C:18]([N:21]([C:28](=[O:35])[CH:29]([OH:31])[CH3:30])[CH2:22][CH2:23][OH:24])[C:19]=1[I:20])[CH2:48][OH:45])=[O:7]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 18429292HCID 18429292, compound

Product 1

HCID 18429318HCID 18429318, compoundYield 37%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

N,N′-Bis(2-acetoxypropionyl)-N,N′-bis(2-acetoxyethyl)-3,5-diamino-2,4,6-triiodobenzylacetate (175 mg, 0.18 mmol) was dissolved in a mixture of methanol (8 ml) and water (8 ml) and pH was adjusted to 12 with 1 M aqueous NaOH. After stirring for 3 h, the solution was neutralized with aqueous HCl. Purification by preparative HPLC gave 50 mg (37%) of the pure product.

Workup

  1. customPurification by preparative HPLC

Sources & evidence

ORD record
ord-b024c90fb3364223afe84e09e8d3f9b9
Source dataset
uspto-grants-2001_10
Patent number
US06310243B1

Reaction notes

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