HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Dimethyl-1,3-dioxolane-4-carbonyl chloride → 3,5-Bis(2,2-dimethyl-1,3-dioxolane-4-carbamido)-2,4,6-triiodo-(2-acetoxyethyl)-benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Dimethyl-1,3-dioxolane-4-carbonyl chloride | HCID 13974813 | — |
| Reactant | 3,5-Diamino-2,4,6-triiodo-(2-acetoxyethyl)benzene | HCID 18429166 | — |
| Product | 3,5-Bis(2,2-dimethyl-1,3-dioxolane-4-carbamido)-2,4,6-triiodo-(2-acetoxyethyl)-benzene | HCID 86754866 | 47% |
Reaction Steps
3,5-Diamino-2,4,6-triiodo-(2-acetoxyethyl)benzene was acylated with 2,2-dimethyl-1,3-dioxolane-4-carboxylic chloride (prepared in situ) according to the procedure in Example 29a. After work up, the product was purified by preparative HPLC and isolated in 47% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310243B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-231ac2b0092f42e997c8df3f5efe2c07 |
| Source note | uspto-grants-2001_10 |