Cesium carbonate → HCID 18429323, compound

HRID 383050Notes

Reaction equation

[C:1]([O:4][CH:5]([CH3:42])[C:6]([NH:8][C:9]1[C:10]([I:41])=[C:11]([CH2:36][O:37][C:38](=[O:40])[CH3:39])[C:12]([I:35])=[C:13]([C:33]=1[I:34])[C:14]([NH:16][CH:17]([CH:23]([O:29][C:30](=[O:32])[CH3:31])[CH2:24][O:25][C:26](=[O:28])[CH3:27])[CH2:18][O:19][C:20](=[O:22])[CH3:21])=[O:15])=[O:7])(=[O:3])[CH3:2].[C:43]([O:46][CH2:47][CH2:48]Br)(=[O:45])[CH3:44].C(=O)([O-])[O-].[Cs+].[Cs+]>>[C:43]([O:46][CH2:47][CH2:48][N:8]([C:6](=[O:7])[CH:5]([O:4][C:1](=[O:3])[CH3:2])[CH3:42])[C:9]1[C:10]([I:41])=[C:11]([CH2:36][O:37][C:38](=[O:40])[CH3:39])[C:12]([I:35])=[C:13]([C:33]=1[I:34])[C:14]([NH:16][CH:17]([CH:23]([O:29][C:30](=[O:32])[CH3:31])[CH2:24][O:25][C:26](=[O:28])[CH3:27])[CH2:18][O:19][C:20](=[O:22])[CH3:21])=[O:15])(=[O:45])[CH3:44]

Participants

Reactant 3

HCID 10796Cesium carbonate

HCID 135641-Acetoxy-2-bromoethane

HCID 18429155HCID 18429155, compound

Product 1

HCID 18429323HCID 18429323, compound

Procedure

5-(2-Acetoxypropionylamino)-3-acetoxymethyl-N-(1,3,4-triacetoxybut-2-yl)-2,4,6-triiodobenzamide (Example 37a) was N-alkylated using 2-bromoethyl acetate and cesium carbonate according to the procedure in Example 30a. The yield of isolated product was 82.4%.

Sources & evidence

ORD record: ord-db2cc77ca9b648b08a81ba0e7b2e6f5b
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06310243B1

Reaction notes

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