HRID383112

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID688405

(4R)-3-(tert-Butoxycarbonyl)-1,3-thiazolidine-4-carboxylic acid

C9H15NO4S

结构：COC(=O)[C@H](CCSC)NC(=O)c1ccc(N)cc1-c1ccccc1

HCID18666758

未命名化合物

2 次

PRODUCTS

生成物

结构：COC(=O)[C@H](CCSC)NC(=O)c1ccc(NC(=O)[C@@H]2CSCN2C(=O)OC(C)(C)C)cc1-c1ccccc1

HCID54440271

未命名化合物

PROCEDURE

实验过程

The desired compound was prepared by coupling of N-tert-butoxycarbonyl-(R)-(−) thiazolidine-4-carboxylic acid, prepared as in Example 164A with [4-amino-2-phenylbenzoyl]methionine methyl ester (compound 8) according to the method of Example 163D.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6d218c732f0e47ef8533799824ed25d3
来源数据集: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06310095B1
来源说明: uspto-grants-2001_10

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[C@H:12]([C:13]([OH:15])=O)[CH2:11][S:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:16][O:17][C:18](=[O:40])[C@H:19]([CH2:36][CH2:37][S:38][CH3:39])[NH:20][C:21](=[O:35])[C:22]1[CH:27]=[CH:26][C:25]([NH2:28])=[CH:24][C:23]=1[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[CH3:16][O:17][C:18](=[O:40])[C@H:19]([CH2:36][CH2:37][S:38][CH3:39])[NH:20][C:21](=[O:35])[C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:13]([C@@H:12]2[CH2:11][S:10][CH2:9][N:8]2[C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])=[O:15])=[CH:24][C:23]=1[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1