HRID383116

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)[C@H](CCSC)NC(=O)c1ccc(N)cc1-c1ccccc1

HCID18666758

未命名化合物

2 次

HCID20699040

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](CCSC)NC(=O)c1ccc(NC[C@@H]2CSCN2C(=O)OC(C)(C)C)cc1-c1ccccc1

HCID54554572

未命名化合物

PROCEDURE

实验过程

N-tert-butoxycarbonyl-(R)-(−)thiazolidine-4-carboxaldehyde was reductively aminated with 4-amino-2-phenylbenzoyl methionine methyl ester (compound 8) according to the procedure of Example 158B.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ee0c4085a93649f5bf7eb66f8693ea6e
来源数据集: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06310095B1
来源说明: uspto-grants-2001_10

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[C@H:12]([CH:13]=O)[CH2:11][S:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:15][O:16][C:17](=[O:39])[C@H:18]([CH2:35][CH2:36][S:37][CH3:38])[NH:19][C:20](=[O:34])[C:21]1[CH:26]=[CH:25][C:24]([NH2:27])=[CH:23][C:22]=1[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[CH3:15][O:16][C:17](=[O:39])[C@H:18]([CH2:35][CH2:36][S:37][CH3:38])[NH:19][C:20](=[O:34])[C:21]1[CH:26]=[CH:25][C:24]([NH:27][CH2:13][C@@H:12]2[CH2:11][S:10][CH2:9][N:8]2[C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])=[CH:23][C:22]=1[C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1