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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 383116Generated: November 1, 2026

N-(4-Amino-2-phenylbenzoyl)methionine methyl ester → [4-(N-tert-butoxycarbonyl-(R)-thiazolidin-4-ylmethyl)amino-2-phenylbenzoyl]methionine methyl ester

https://huagongshe.com/reaction/383116

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(4-Amino-2-phenylbenzoyl)methionine methyl esterHCID 18666758—
ReactantN-tert-butoxycarbonyl-(R)-(-)thiazolidine-4-carboxaldehydeHCID 20699040—
Product[4-(N-tert-butoxycarbonyl-(R)-thiazolidin-4-ylmethyl)amino-2-phenylbenzoyl]methionine methyl esterHCID 54554572—

Reaction Steps

N-tert-butoxycarbonyl-(R)-(−)thiazolidine-4-carboxaldehyde was reductively aminated with 4-amino-2-phenylbenzoyl methionine methyl ester (compound 8) according to the procedure of Example 158B.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06310095B1
Source datasetuspto-grants-2001_10
ORD IDord-ee0c4085a93649f5bf7eb66f8693ea6e
Source noteuspto-grants-2001_10