反应详情

A solution of DL, 2-hydroxy-4-methylmercaptobutyric acid calcium salt (2.2 g) in 0.5M HCl (50 mL) was saturated with sodium chloride, extracted exhaustively with EtOAc, which was dried (MgSO4), filtered and concentrated. The residue was dissolved in methanol (10 mL) and trimethylsilyldiazomethane (2M in hexane) was added until the yellow color persisted for 30 min. The reaction was quenched by addition of glacial acetic acid and concentrated. The residue was purified by silica gel chromatography eluting with 30% EtOAc/hexane to give the title compound as a light yellow oil (1.37 g).

1. extractionextracted exhaustively with EtOAc, which
2. dry with materialwas dried (MgSO4)
3. filtrationfiltered
4. concentrationconcentrated
5. dissolutionThe residue was dissolved in methanol (10 mL)
6. additiontrimethylsilyldiazomethane (2M in hexane) was added until the yellow color
7. customThe reaction was quenched by addition of glacial acetic acid
8. concentrationconcentrated
9. customThe residue was purified by silica gel chromatography
10. washeluting with 30% EtOAc/hexane