2-Morpholinoethylamine → N-[4-(N-(2-Morpholin-4-ylethyl)aminomethyl)-2-(2-methylphenyl)benzoyl]methionine methyl ester

HRID 383166Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:27])[C@H:4]([CH2:23][CH2:24][S:25][CH3:26])[NH:5][C:6](=[O:22])[C:7]1[CH:12]=[CH:11][C:10]([CH:13]=O)=[CH:9][C:8]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[CH3:21].[NH2:28][CH2:29][CH2:30][N:31]1[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1>>[CH3:1][O:2][C:3](=[O:27])[C@H:4]([CH2:23][CH2:24][S:25][CH3:26])[NH:5][C:6](=[O:22])[C:7]1[CH:12]=[CH:11][C:10]([CH2:13][NH:28][CH2:29][CH2:30][N:31]2[CH2:36][CH2:35][O:34][CH2:33][CH2:32]2)=[CH:9][C:8]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[CH3:21]

Participants

Reactant 2

HCID 4082852-Morpholinoethylamine

HCID 10596254HCID 10596254, compound

Product 1

HCID 20698951N-[4-(N-(2-Morpholin-4-ylethyl)aminomethyl)-2-(2-methylphenyl)benzoyl]methionine methyl ester

Procedure

The desired compound was prepared using the method described in Example 403H starting with N-[4-formyl-2-(2-methylphenyl)benzoyl]methionine methyl ester, prepared as in Example 403G, and 4-(2-aminoethyl)morpholine. m/e (ESI) 500 (MH+)

Sources & evidence

ORD record: ord-955a6c3fe4fb4576b0078cf1f3a7aabc
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06310095B1

Reaction notes

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