Pyridine → HCID 131722950, compound

HRID 383171Notes

Reaction equation

HRID 383171 reaction equation
[Cl:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5][CH:4]=1.Cl.[CH3:13][O:14][C:15](=[O:22])[C@H:16]([CH2:18][CH2:19][S:20][CH3:21])[NH2:17].N1C=CC=CC=1>C(Cl)(Cl)Cl>[Cl:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH:17][C@H:16]([C:15]([O:14][CH3:13])=[O:22])[CH2:18][CH2:19][S:20][CH3:21])=[O:8])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 701364-(Chloromethyl)benzoyl chlorideHCID 11435579L-Methionine, methyl ester, hydrochloride

Product 1

HCID 131722950HCID 131722950, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A mixture of 4-(chloromethyl)-benzoyl chloride (0.189 g, 1 mmol), methionine methyl ester hydrochloride (0.199 g, 1 mmol), and 0.5 ml of pyridine in 5 ml of chloroform was stirred for 12 hours. The organic solution was washed with 10% HCl, brine, and dried over MgSO4. Flash chromatography of the residue afforded 0.20 g of desired product (64%).

Workup

  1. washThe organic solution was washed with 10% HCl, brine
  2. dry with materialdried over MgSO4

Sources & evidence

ORD record
ord-65e2d77b835947fbaf64e7186b7178a1
Source dataset
uspto-grants-2001_10
Patent number
US06310095B1

Reaction notes

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