HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 131722950, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 4-(Chloromethyl)benzoyl chloride | HCID 70136 | — |
| Reactant | L-Methionine, methyl ester, hydrochloride | HCID 11435579 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 131722950 | HCID 131722950 | 64% |
Reaction Steps
A mixture of 4-(chloromethyl)-benzoyl chloride (0.189 g, 1 mmol), methionine methyl ester hydrochloride (0.199 g, 1 mmol), and 0.5 ml of pyridine in 5 ml of chloroform was stirred for 12 hours. The organic solution was washed with 10% HCl, brine, and dried over MgSO4. Flash chromatography of the residue afforded 0.20 g of desired product (64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310095B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-65e2d77b835947fbaf64e7186b7178a1 |
| Source note | uspto-grants-2001_10 |