Lithium Hydroxide → HCID 131722951, compound

HRID 383172Notes

Reaction equation

C[O:2][C:3](=[S:37])[C@H:4]([CH2:32][CH2:33][C:34](=[O:36])[NH2:35])[NH:5][C:6](=[O:31])[C:7]1[CH:12]=[CH:11][C:10]([CH2:13][N:14]([CH2:16][CH2:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)[CH3:15])=[CH:9][C:8]=1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[CH3:30].[Li+:38].[OH-]>>[Li+:38].[CH:18]1([CH2:17][CH2:16][N:14]([CH2:13][C:10]2[CH:11]=[CH:12][C:7]([C:6]([NH:5][C@H:4]([C:3]([O-:2])=[S:37])[CH2:32][CH2:33][C:34](=[O:36])[NH2:35])=[O:31])=[C:8]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[CH3:30])[CH:9]=2)[CH3:15])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 88019334HCID 88019334, compound

Product 1

HCID 131722951HCID 131722951, compound

Procedure

N-[4-(N-(2-cyclohexylethyl)-N-methylaminomethyl)-2-(2-methylphenyl)benzoyl]thioglutamine methyl ester (12 mg, 22.9 μmol) was saponified using the standard LiOH procedure, evaporated, and lyophilized from water to provide 9.8 mg of the title compound. MS m/e 514 (M−H)−.

Workup

customevaporated

Sources & evidence

ORD record: ord-bce243d4f9a441fe9cff648a2a39f541
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06310095B1

Reaction notes

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