Chloromethyl Methyl Ether → N-methoxymethyl-N-methylpyrrolidinium chloride

Temperature

5 °C

A 30.0 g quantity of N-methylpyrrolidine (reagent, product of Tokyo Kasei Co., Ltd.) was dissolved in 120 g of toluene, followed by replacement with nitrogen. Chloromethyl methyl ether (31.2 g, reagent, product of Tokyo Kasei Co., Ltd.) was added dropwise to the solution at 5° C. over a period of 1 hour. The mixture was stirred at 5° C. for 1 hour, then gradually heated to a higher temperature, and stirred at room temperature for 10 hours to complete the reaction. The reaction mixture was filtered, and the resulting solid product was washed with 150 g of toluene and 150 g of acetone. The washed product was dried in a vacuum to obtain 53.7 g of the desired product (white solid).

1. temperaturegradually heated to a higher temperature
2. stirringstirred at room temperature for 10 hours
3. customthe reaction
4. filtrationThe reaction mixture was filtered
5. washthe resulting solid product was washed with 150 g of toluene and 150 g of acetone
6. customThe washed product was dried in a vacuum

ORD record

ord-2297c9ba132c47f2a98b1e2367a9b2a2

Source dataset

uspto-grants-2013_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08366956B2