Trifluoromethanesulfonic acid → Trifluoromethanesulfonic acid
Reaction equation
[Cl-].[CH3:2][O:3][CH2:4][N+:5]1([CH3:10])[CH2:9][CH2:8][CH2:7][CH2:6]1.[F:11][C:12]([F:18])([F:17])[S:13]([OH:16])(=[O:15])=[O:14]>CO>[F:11][C:12]([F:18])([F:17])[S:13]([OH:16])(=[O:15])=[O:14].[CH3:2][O:3][CH2:4][N+:5]1([CH3:10])[CH2:9][CH2:8][CH2:7][CH2:6]1Participants
5
Reactant 2
Product 2
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 130 °C
Procedure
A 30.0 g quantity of N-methoxymethyl-N-methylpyrrolidinium chloride prepared in Example 10 was dissolved in 30.0 g of MeOH, and 80.0 g of methanol solution of 35 wt. % trifluoromethanesulfonic acid was added to the solution. The mixture was heated at 130° C. in a nitrogen stream to remove hydrogen chloride produced as a by-product, an excess of trifluoromethanesulfonic acid and methanol, giving 49.0 g of the desired product.
Workup
- customto remove hydrogen chloride
- customproduced as a by-product
Sources & evidence
- ORD record
- ord-0b519d05882442eeb1c0ab17562a45fa
- Source dataset
- uspto-grants-2013_02
- Patent number
- US08366956B2
Reaction notes
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