Ethyl Acetate → HCID 59718775, compound

HRID 383538Notes

Reaction equation

HRID 383538 reaction equation
C(OCC)(=O)C.[C:7]([O:11][C:12]([NH:14][C:15]1([CH:21]=[CH:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)=[O:13])([CH3:10])([CH3:9])[CH3:8].[H][H]>[C].[Pd].CO>[C:7]([O:11][C:12]([NH:14][C:15]1([CH2:21][CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)=[O:13])([CH3:10])([CH3:9])[CH3:8]

Participants

6

Reactant 3

HCID 8857Ethyl AcetateHCID 59718868HCID 59718868, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 59718775HCID 59718775, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

In the ethyl acetate (30 mL) and methanol (12 mL) mixed solution of ethyl 3-(4-t-butoxycarbonylamino-tetrahydro-pyran-4-yl)-acrylate which had been obtained in 3), 5% palladium carbon catalyst was added at room temperature. The reaction mixture was stirred under the hydrogen gas stream at room temperature for 75 minutes. The palladium catalyst was removed by filtration with Celite, and the filtrate was concentrated and dried up to give colorless oily matter (2.69 g).

Workup

  1. additionwas added at room temperature
  2. customThe palladium catalyst was removed by filtration with Celite
  3. concentrationthe filtrate was concentrated
  4. customdried up
  5. customto give colorless oily matter (2.69 g)

Sources & evidence

ORD record
ord-1d689a5a13c34b91a2149ac10104d147
Source dataset
uspto-grants-2013_02
Patent number
US08367666B2

Reaction notes

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