Hydrogen chloride-ethyl acetate → HCID 67519776, compound

HRID 383539Notes

Reaction equation

HRID 383539 reaction equation
[ClH:1].C(OCC)(=O)C.C(OC([NH:15][C:16]1([CH2:22][CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1)=O)(C)(C)C>C(OCC)(=O)C>[ClH:1].[NH2:15][C:16]1([CH2:22][CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH2:17][CH2:18][O:19][CH2:20][CH2:21]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetate2×HCID 59718775HCID 59718775, compound

Product 1

HCID 67519776HCID 67519776, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N hydrochloric acid-ethyl acetate solution (12.9 mL, 51.6 mmol) was added in a ethyl acetate (40 mL) solution of ethyl 3-(4-t-butoxycarbonylamino-tetrahydro-pyran-4-yl)-propionate (2.59 g, 8.6 mmol), which had been obtained in 4), in an ice bath. The reaction mixture was stirred at room temperature for 4 hours, and 4N hydrochloric acid-ethyl acetate solution (4.3 mL, 17.2 mmol) was added and the reaction mixture was further stirred at room temperature for 1 hour. The formed solid was filtered to give a colorless solid (BB05, 1.28 g).

Workup

  1. customhad been obtained in 4), in an ice bath
  2. stirringthe reaction mixture was further stirred at room temperature for 1 hour
  3. filtrationThe formed solid was filtered
  4. customto give a colorless solid (BB05, 1.28 g)

Sources & evidence

ORD record
ord-2837e435d572476d9c1840759e08704f
Source dataset
uspto-grants-2013_02
Patent number
US08367666B2

Reaction notes

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