HCID 59718741, compound → HCID 59718788, compound

HRID 383546Notes

Reaction equation

HRID 383546 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:6][C:5]=1[C:21]([F:24])([F:23])[F:22])([O-])=O>[C].[Pd].C(OCC)(=O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:6][C:5]=1[C:21]([F:22])([F:23])[F:24]

Participants

4

Reactant 1

HCID 59718741HCID 59718741, compound

Product 1

HCID 59718788HCID 59718788, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

10% palladium carbon (0.1 g) was added in the ethyl acetate (20 mL) solution of diethyl 2-(4-nitro-3-trifluoromethyl-phenyl)-malonate (1.1 g, 3.15 mmol) which had been obtained in 1), and the solution was hydrogenated. After the catalyst was removed by filtration, the solvent was concentrated under reduced pressure and yellow oily diethyl 2-(4-amino-3-trifluoromethyl-phenyl)-malonate (1.38 g (the content of 0.39%), 68%) was obtained, and the product was used in the next reaction without purification.

Workup

  1. customhad been obtained in 1), and the solution
  2. customAfter the catalyst was removed by filtration
  3. concentrationthe solvent was concentrated under reduced pressure and yellow oily diethyl 2-(4-amino-3-trifluoromethyl-phenyl)-malonate (1.38 g (the content of 0.39%), 68%)
  4. customwas obtained
  5. customthe product was used in the next reaction without purification

Sources & evidence

ORD record
ord-8dbbec132bd74e39a5ca292adad38c77
Source dataset
uspto-grants-2013_02
Patent number
US08367666B2

Reaction notes

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