反应详情

26 mmol of ethyl{3-[6-oxo-3-(4-cyanophenyl)-6H-pyridazin-1-ylmethyl]-phenyl}carbamate are dissolved in 300 ml of methanolic ammonia solution (10%), 4 g of Raney Ni are added, and the mixture is hydrogenated at room temperature for 16 h under a hydrogen atmosphere (5 bar). The catalyst is separated off, rinsed with methanol, and the filtrate is evaporated.

1. customThe catalyst is separated off
2. washrinsed with methanol
3. customthe filtrate is evaporated