4-(Bromoacetyl)pyridine hydrobromide → Ethyl{3-[6-oxo-3-(4-pyridin-4-ylthiazol-2-yl)-6h-pyridazin-1-ylmethyl]phenyl}carbamate
Reaktionsgleichung
[CH2:1]([O:3][C:4](=[O:23])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][N:13]2[C:18](=[O:19])[CH:17]=[CH:16][C:15]([C:20](=[S:22])[NH2:21])=[N:14]2)[CH:7]=1)[CH3:2].Br.Br[CH2:26][C:27]([C:29]1[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=1)=O>CCO>[CH2:1]([O:3][C:4](=[O:23])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][N:13]2[C:18](=[O:19])[CH:17]=[CH:16][C:15]([C:20]3[S:22][CH:26]=[C:27]([C:29]4[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=4)[N:21]=3)=[N:14]2)[CH:7]=1)[CH3:2]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 80 °C
Versuchsvorschrift
100 mg (0.30 mmol) of ethyl[3-(6-oxo-3-thiocarbamoyl-6H-pyridazin-1-yl-methyl)phenyl]carbamate are suspended in 2 ml of EtOH, and 101 mg (0.36 mmol) of 2-bromo-1-(4-pyridinyl)ethanone hydrobromide are added. The reaction mixture is stirred at 80° C. for 15 h. The precipitate formed is filtered off with suction and washed with ethanol and dried in vacuo. The crude product is purified by means of preparative HPLC.
Aufarbeitung
- customThe precipitate formed
- filtrationis filtered off with suction
- washwashed with ethanol
- customdried in vacuo
- customThe crude product is purified by means of preparative HPLC
Quellen und Nachweise
- ORD-Eintrag
- ord-5ef37ea386ea41d5b655fc0b2103aa09
- Quelldatensatz
- uspto-grants-2013_02
- Patentnummer
- US08367668B2
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