HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 383646Generated: October 26, 2026
4-(Bromoacetyl)pyridine hydrobromide → Ethyl{3-[6-oxo-3-(4-pyridin-4-ylthiazol-2-yl)-6h-pyridazin-1-ylmethyl]phenyl}carbamate
https://huagongshe.com/reaction/383646
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-(Bromoacetyl)pyridine hydrobromide | HCID 2776239 | — |
| Reactant | Ethyl[3-(6-oxo-3-thiocarbamoyl-6h-pyridazin-1-yl-methyl)phenyl]carbamate | HCID 59406698 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl{3-[6-oxo-3-(4-pyridin-4-ylthiazol-2-yl)-6h-pyridazin-1-ylmethyl]phenyl}carbamate | HCID 59406721 | — |
Reaction Steps
100 mg (0.30 mmol) of ethyl[3-(6-oxo-3-thiocarbamoyl-6H-pyridazin-1-yl-methyl)phenyl]carbamate are suspended in 2 ml of EtOH, and 101 mg (0.36 mmol) of 2-bromo-1-(4-pyridinyl)ethanone hydrobromide are added. The reaction mixture is stirred at 80° C. for 15 h. The precipitate formed is filtered off with suction and washed with ethanol and dried in vacuo. The crude product is purified by means of preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367668B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-5ef37ea386ea41d5b655fc0b2103aa09 |
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| Source note | uspto-grants-2013_02 |
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