関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydantoin | HCID 10006 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Ammonium Acetate | HCID 517165 | — |
| 反応物 | 5-Chloropyrazolo(1,5-a)pyrimidine-3-carbaldehyde | HCID 58196401 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | HCID 178507865 | HCID 178507865 | — |
反応手順
To 5-chloropyrazolo[1,5-a]pyrimidine-3-carbaldehyde (50 mg, 0.276 mmol) in EtOH was added hydantoin (38 mg, 0.380 mmol), DIEA (5 μL, 0.028 mmol), and ammonium acetate (88 mg, 1.143 mmol). The mixture was heated at 70° C. overnight. The solid formed was isolated by filtration and purified by HPLC to yield 5-((5-aminopyrazolo[1,5-a]pyrimidin-3-yl)methylene)imidazolidine-2,4-dione. LCMS (M+1=245)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08367681B2 |
|---|
| 出典データセット | uspto-grants-2013_02 |
|---|
| ORD ID | ord-e80db8cbb0c443819fc023b1b6bc453e |
|---|
| 出典メモ | uspto-grants-2013_02 |
|---|
