Hydantoin → HCID 178507865, 화합물

HRID 383665노트

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HRID 383665 반응식
Cl[C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[CH:9][C:10]([CH:11]=O)=[C:4]2[N:3]=1.[NH:13]1[CH2:19][C:17](=[O:18])[NH:16][C:14]1=[O:15].CC[N:22](C(C)C)C(C)C.C([O-])(=O)C.[NH4+]>CCO>[NH2:22][C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[CH:9][C:10]([CH:11]=[C:19]3[NH:13][C:14](=[O:15])[NH:16][C:17]3=[O:18])=[C:4]2[N:3]=1

참가 물질

6

반응물 4

HCID 10006HydantoinHCID 81531DiisopropylethylamineHCID 517165Ammonium AcetateHCID 581964015-Chloropyrazolo(1,5-a)pyrimidine-3-carbaldehyde

생성물 1

HCID 178507865HCID 178507865, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
70 °C

실험 절차

To 5-chloropyrazolo[1,5-a]pyrimidine-3-carbaldehyde (50 mg, 0.276 mmol) in EtOH was added hydantoin (38 mg, 0.380 mmol), DIEA (5 μL, 0.028 mmol), and ammonium acetate (88 mg, 1.143 mmol). The mixture was heated at 70° C. overnight. The solid formed was isolated by filtration and purified by HPLC to yield 5-((5-aminopyrazolo[1,5-a]pyrimidin-3-yl)methylene)imidazolidine-2,4-dione. LCMS (M+1=245)

후처리

  1. customThe solid formed
  2. customwas isolated by filtration
  3. custompurified by HPLC

출처 및 근거

ORD 기록
ord-e80db8cbb0c443819fc023b1b6bc453e
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367681B2

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