Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Hydantoin | HCID 10006 | — |
| Reactant | 5-(3-Chlorophenoxy)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde | HCID 58196625 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 66821266 | HCID 66821266 | — |
Reaction Steps
To 5-(3-chlorophenoxy)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde (30 mg, 0.109 mmol) in DMF was added hydantoin (10.9 mg, 0.109 mmol) and piperidine (21.8 μL, 0.218 mmol). The mixture was heated at 70° C. Added water, and the solid formed was isolated by filtration to yield 5-((5-(piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)methylene)imidazolidine-2,4-dione. LCMS (M+1=313)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08367681B2 |
|---|
| Source dataset | uspto-grants-2013_02 |
|---|
| ORD ID | ord-b84f8ffceb3d4d25b3f5e94c678b8371 |
|---|
| Source note | uspto-grants-2013_02 |
|---|
