Water → HCID 66821266, compound

HRID 383671Notes

Reaction equation

ClC1C=C(C=CC=1)O[C:6]1[CH:11]=[CH:10][N:9]2[N:12]=[CH:13][C:14]([CH:15]=O)=[C:8]2[N:7]=1.[NH:20]1[CH2:26][C:24](=[O:25])[NH:23][C:21]1=[O:22].[NH:27]1[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1.O>CN(C=O)C>[N:27]1([C:6]2[CH:11]=[CH:10][N:9]3[N:12]=[CH:13][C:14]([CH:15]=[C:26]4[NH:20][C:21](=[O:22])[NH:23][C:24]4=[O:25])=[C:8]3[N:7]=2)[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1

Participants

Conditions

Temperature: 70 °C

Procedure

To 5-(3-chlorophenoxy)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde (30 mg, 0.109 mmol) in DMF was added hydantoin (10.9 mg, 0.109 mmol) and piperidine (21.8 μL, 0.218 mmol). The mixture was heated at 70° C. Added water, and the solid formed was isolated by filtration to yield 5-((5-(piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)methylene)imidazolidine-2,4-dione. LCMS (M+1=313)

Workup

customwas isolated by filtration

Sources & evidence

ORD record: ord-b84f8ffceb3d4d25b3f5e94c678b8371
Source dataset: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08367681B2

Reaction notes

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