反应详情

温度

90 °C

To a solution of 3-methyl-1-(2-methylsulfanyl-pyrimidin-4-yl)-butan-2-one (4.3 g, 20.5 mmol) in anhydrous toluene (20 mL) is added N,N-dimethylformamide dimethylacetal (15.0 mL, 112.9 mmol). The reaction is heated at 90° C. for 4 h. The mixture is concentrated in vacuo to give the crude product, 1-dimethylamino-4-methyl-2-(2-methylsulfanyl-pyrimidin-4-yl)-pent-1-en-3-one. The crude product is used as it is.

1. concentrationThe mixture is concentrated in vacuo