4-Bromobenzyl bromide → 4-broMobenzyl)(Methyl)sulfane

Temperature

60 °C

Sodium thiomethoxide (1.0 g, 14.3 mmol) and 4-bromobenzyl bromide (2.65 g, 10.6 mmol) were combined with anhyd THF (50 mL) and the reaction mixture was stirred at 60° C. After 3 h the reaction mixture was concentrated in vacuo and the residue was washed into a separatory funnel with EtOAc and water. The organic layer was separated, dried (anhyd MgSO4), and concentrated in vacuo to yield 1-bromo-4-methylthiomethyl-benzene. To a solution of this crude thioether in DCM (100 mL) was added 3-chloroperoxybenzoic acid (77%, 4.0 g) portionwise. After stirring overnight the reaction mixture was poured into a separatory funnel, washed with 1N NaOH, dried (Na2SO4), and concentrated in vacuo. The residue was crystallized from EtOAc-Hex to afford 1-bromo-4-methanesulfonylmethyl-benzene (2.02 g, 76%) as light tan needles:

1. concentrationAfter 3 h the reaction mixture was concentrated in vacuo
2. washthe residue was washed into a separatory funnel with EtOAc and water
3. customThe organic layer was separated
4. dry with materialdried (anhyd MgSO4)
5. concentrationconcentrated in vacuo

ORD record

ord-6243c3ab7f544a968e186924c7da879e

Source dataset

uspto-grants-2013_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08367667B2