Ammonia → HCID 59807763, compound

HRID 383760Notes

Reaction equation

[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([C:14]2[CH:18]=[C:17]([CH3:19])[N:16]([C:20]3[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=3[C:22]([OH:24])=O)[C:15]=2[CH3:29])=[O:13])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[NH3:30]>>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([NH:11][C:12]([C:14]2[CH:18]=[C:17]([CH3:19])[N:16]([C:20]3[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=3[C:22](=[O:24])[NH2:30])[C:15]=2[CH3:29])=[O:13])=[CH:9][CH:10]=1)(=[O:3])=[O:4]

Participants

Reactant 2

HCID 222Ammonia

HCID 59808009HCID 59808009, compound

Product 1

HCID 59807763HCID 59807763, compound

Procedure

In a manner similar to that described for Examples 1B-C, the title compound was prepared from 2-[3-(4-methanesulfonyl-phenylcarbamoyl)-2,5-dimethyl-pyrrol-1-yl]-benzoic acid and ammonia. 1H-NMR (DMSO-d6): δ 9.82 (1H, s), 8.08 (2H, d, J=9.1), 7.90 (2H, d, J=9.1), 7.67 (4H, m), 7.39 (1H, s). 7.34 (1H, m), 6.63 (1H, s), 3.23 (3H, s), 2.27 (3H, s), 2.00 (3H, s); MS (ESI): 412 (MH+). C. In a manner similar to that described for Example 21B, the following compounds were prepared from the appropriate amines:

Sources & evidence

ORD record: ord-6be91103895a470f9b80f5bf5a8e42c1
Source dataset: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08367667B2

Reaction notes

Loading…