Methyl 4-[(3-pyridin-3-ylpyrrolidin-1-yl)carbonyl]-3',5'-bis(trifluoromethyl)biphenyl-2-carboxylate → 4-[(3-Pyridin-3-ylpyrrolidin-1-yl)carbonyl]-3',5'-bis(trifluoromethyl)biphenyl-2-carboxylic acid

HRID 383779Notes

Reaction equation

HRID 383779 reaction equation
BrC1C=C(C(O)=O)C=CC=1C1C=C(C(F)(F)F)C=C(C(F)(F)F)C=1.[N:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH:31]2[CH2:35][CH2:34][N:33]([C:36]([C:38]3[CH:39]=[C:40]([C:58]([O:60]C)=[O:59])[C:41]([C:44]4[CH:49]=[C:48]([C:50]([F:53])([F:52])[F:51])[CH:47]=[C:46]([C:54]([F:57])([F:56])[F:55])[CH:45]=4)=[CH:42][CH:43]=3)=[O:37])[CH2:32]2)[CH:26]=1>>[N:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH:31]2[CH2:35][CH2:34][N:33]([C:36]([C:38]3[CH:39]=[C:40]([C:58]([OH:60])=[O:59])[C:41]([C:44]4[CH:49]=[C:48]([C:50]([F:52])([F:53])[F:51])[CH:47]=[C:46]([C:54]([F:55])([F:56])[F:57])[CH:45]=4)=[CH:42][CH:43]=3)=[O:37])[CH2:32]2)[CH:26]=1

Participants

3

Reactant 2

HCID 46847415Methyl 4-[(3-pyridin-3-ylpyrrolidin-1-yl)carbonyl]-3',5'-bis(trifluoromethyl)biphenyl-2-carboxylateHCID 866577562-Bromo-3',5'-bis(trifluoromethyl)biphenyl-4-carboxylic acid

Product 1

HCID 468474134-[(3-Pyridin-3-ylpyrrolidin-1-yl)carbonyl]-3',5'-bis(trifluoromethyl)biphenyl-2-carboxylic acid

Procedure

Compound 7b was prepared following procedures similar to those described for the preparation of compound 3a (example 3, step A), substituting 7a for i-1b. m/z (ES) 509 (MH)+.

Sources & evidence

ORD record
ord-6b975d35ba324e91b64631cd21a537c6
Source dataset
uspto-grants-2013_02
Patent number
US08367679B2

Reaction notes

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