HRID383779

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)c1cc(C(=O)N2CCC(c3cccnc3)C2)ccc1-c1cc(C(F)(F)F)cc(C(F)(F)F)c1

HCID46847415

未命名化合物

结构：O=C(O)c1ccc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(Br)c1

HCID86657756

未命名化合物

PRODUCTS

生成物

结构：O=C(O)c1cc(C(=O)N2CCC(c3cccnc3)C2)ccc1-c1cc(C(F)(F)F)cc(C(F)(F)F)c1

HCID46847413

未命名化合物

PROCEDURE

实验过程

Compound 7b was prepared following procedures similar to those described for the preparation of compound 3a (example 3, step A), substituting 7a for i-1b. m/z (ES) 509 (MH)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6b975d35ba324e91b64631cd21a537c6
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08367679B2
来源说明: uspto-grants-2013_02

反应 SMILES

BrC1C=C(C(O)=O)C=CC=1C1C=C(C(F)(F)F)C=C(C(F)(F)F)C=1.[N:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH:31]2[CH2:35][CH2:34][N:33]([C:36]([C:38]3[CH:39]=[C:40]([C:58]([O:60]C)=[O:59])[C:41]([C:44]4[CH:49]=[C:48]([C:50]([F:53])([F:52])[F:51])[CH:47]=[C:46]([C:54]([F:57])([F:56])[F:55])[CH:45]=4)=[CH:42][CH:43]=3)=[O:37])[CH2:32]2)[CH:26]=1>>[N:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH:31]2[CH2:35][CH2:34][N:33]([C:36]([C:38]3[CH:39]=[C:40]([C:58]([OH:60])=[O:59])[C:41]([C:44]4[CH:49]=[C:48]([C:50]([F:52])([F:53])[F:51])[CH:47]=[C:46]([C:54]([F:55])([F:56])[F:57])[CH:45]=4)=[CH:42][CH:43]=3)=[O:37])[CH2:32]2)[CH:26]=1