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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 383779Generated: October 26, 2026

Methyl 4-[(3-pyridin-3-ylpyrrolidin-1-yl)carbonyl]-3',5'-bis(trifluoromethyl)biphenyl-2-carboxylate → 4-[(3-Pyridin-3-ylpyrrolidin-1-yl)carbonyl]-3',5'-bis(trifluoromethyl)biphenyl-2-carboxylic acid

https://huagongshe.com/reaction/383779

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 4-[(3-pyridin-3-ylpyrrolidin-1-yl)carbonyl]-3',5'-bis(trifluoromethyl)biphenyl-2-carboxylateHCID 46847415—
Reactant2-Bromo-3',5'-bis(trifluoromethyl)biphenyl-4-carboxylic acidHCID 86657756—
Product4-[(3-Pyridin-3-ylpyrrolidin-1-yl)carbonyl]-3',5'-bis(trifluoromethyl)biphenyl-2-carboxylic acidHCID 46847413—

Reaction Steps

Compound 7b was prepared following procedures similar to those described for the preparation of compound 3a (example 3, step A), substituting 7a for i-1b. m/z (ES) 509 (MH)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08367679B2
Source datasetuspto-grants-2013_02
ORD IDord-6b975d35ba324e91b64631cd21a537c6
Source noteuspto-grants-2013_02