反应详情

To the solution of methyl 5-aminopyridine-3-carboxylate (700.0 mg) in MeOH (20 ml) was added 2 M aqueous solution of HCl (7 ml). And the mixture was hydrogenated (ca. 4 atm) for 1 day in a Parr low-pressure hydrogenation apparatus with a 5 wt. % Rh on Al2O3 catalyst (451.9 mg) at 80° C. Rh on Al2O3 catalyst was filtered off and the filtrate was concentrated in vacuo. The residue was solidified from the mixed solvent of CHCl3 and MeOH to give methyl cis-5-aminopiperidine-3-carboxylate dihydrochloride as a cream-colored solid.

1. customfor 1 day
2. customat 80° C
3. filtrationRh on Al2O3 catalyst was filtered off
4. concentrationthe filtrate was concentrated in vacuo