HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzylpiperazine → 7-(4-Benzyl-piperazin-1-yl)-benzofuran-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzylpiperazine | HCID 75994 | — |
| Reactant | Ethyl 7-bromobenzofuran-2-carboxylate | HCID 46738833 | — |
| Product | 7-(4-Benzyl-piperazin-1-yl)-benzofuran-2-carboxylic acid ethyl ester | HCID 59636745 | — |
Reaction Steps
The compound was prepared according to the procedure disclosed in Example 1a starting from benzylpiperazine (16.1 mL, 92.6 mmol) and 7-bromo-benzofuran-2-carboxylic acid ethyl ester (16.6 g, 61.7 mmol). The product was purified by flash chromatography (SiO2; hexane/EtOAc, gradient 0-50%). Yield: 14 g (63%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367676B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-ab2da4472f894810b39b12f88afabf61 |
| Source note | uspto-grants-2013_02 |