反应详情

温度

115 °C

The reaction mixture of 1-(6-bromopyridin-3-yl)ethanone (0.68 g, 3.41 mmol), 2,4,6-trivinyl-1,3,5,2,4,6-trioxatriborinane:pyridine (1:1) (0.57 g, 2.39 mmol), potassium carbonate (0.85 g, 6.14 mmol), and Pd(Ph3P)4 (0.16 g, 0.14 mmol) in acetonitrile (10 mL) was degassed with argon for 5 minutes. Then it was heated in the microwave for 30 min at 115° C. The organic phase was removed using a pipette, dried (MgSO4), filtered and concentrated and purified by flash chromatography (SiO2; heptane/EtOAc, gradient 20-80%). Yield: 0.36 g (72%).

1. customwas degassed with argon for 5 minutes
2. customThe organic phase was removed
3. dry with materialdried (MgSO4)
4. filtrationfiltered
5. concentrationconcentrated
6. custompurified by flash chromatography (SiO2; heptane/EtOAc, gradient 20-80%)