HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 383832Generated: October 25, 2026
Acetic Acid → Azetidin-1-yl(7-(4-(2-(6-methoxypyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-yl)methanone
https://huagongshe.com/reaction/383832
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 2-Methoxy-6-vinylpyridine | HCID 19091566 | — |
| Reactant | Azetidin-1-yl(7-(piperazin-1-yl)benzofuran-2-yl)methanone | HCID 59636763 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Azetidin-1-yl(7-(4-(2-(6-methoxypyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-yl)methanone | HCID 59636730 | — |
Reaction Steps
Azetidin-1-yl(7-(piperazin-1-yl)benzofuran-2-yl)methanone (0.070 g, 0.25 mmol) was dissolved in methanol (1 mL). 2-Methoxy-6-vinylpyridine (0.066 g, 0.49 mmol) and acetic acid (0.014 mL, 0.25 mmol) were added. The mixture was heated by microwave irradiation to 120° C. for 10 h. The product was purified by preparative HPLC to give the title compound. Yield: 0.044 g (43%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08367676B2 |
|---|
| Source dataset | uspto-grants-2013_02 |
|---|
| ORD ID | ord-6cde1129c98247938e4fea1f5bc2e6f2 |
|---|
| Source note | uspto-grants-2013_02 |
|---|
