Hydrogen chloride-ethyl acetate → HCID 68430374, compound

HRID 383884Notes

Reaction equation

HRID 383884 reaction equation
[ClH:1].C(OCC)(=O)C.[CH:8]([O:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19]([C@H:21]2[C@H:26]3[CH2:27][CH2:28][C@H:23]([CH2:24][N:25]3C(OC(C)(C)C)=O)[CH2:22]2)=[O:20])=[CH:14][CH:13]=1)([CH3:10])[CH3:9]>C(Cl)(Cl)Cl>[ClH:1].[CH:8]([O:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19]([C@H:21]2[C@H:26]3[CH2:27][CH2:28][C@H:23]([CH2:24][NH:25]3)[CH2:22]2)=[O:20])=[CH:14][CH:13]=1)([CH3:10])[CH3:9]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86649436HCID 86649436, compound

Product 1

HCID 68430374HCID 68430374, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A 4 N-hydrochloric acid-ethyl acetate solution (8.1 mL) was added to a chloroform (10 mL) solution of the compound (1.26 g, 3.24 mmol) synthesized in (3), and the mixture was stirred at room temperature for 13 hours. The reaction mixture was then concentrated under reduced pressure to obtain the title compound (1.15 g, 100%).

Workup

  1. concentrationThe reaction mixture was then concentrated under reduced pressure

Sources & evidence

ORD record
ord-94e93848fc4645118f2fbea65ba3a85b
Source dataset
uspto-grants-2013_02
Patent number
US08367698B2

Reaction notes

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