Hydrazine hydrate (1:1) → 1-Boc-3-(aminomethyl)piperidine

HRID 383890Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 383890
O.NN.O=C1C2C(=CC=CC=2)C(=O)[N:6]1[CH2:15][CH:16]1[CH2:21][CH2:20][CH2:19][N:18]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:17]1>C(O)C>[NH2:6][CH2:15][CH:16]1[CH2:21][CH2:20][CH2:19][N:18]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:17]1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 86649437tert-Butyl 3-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]piperidine-1-carboxylate

Produkt 1

HCID 27564831-Boc-3-(aminomethyl)piperidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Hydrazine monohydrate (1 mL, 20.58 mmol) was added to an ethanol (20 mL) solution of the compound (1.45 g, 4.21 mmol) synthesized in (1), and the mixture was stirred at room temperature for 24 hours. The reaction solution was filtered, and the filtrate was concentrated under reduced pressure. The residue was re-suspended in ethanol, and allowed to stand under ice-cooled conditions. After filtration, the filtrate was concentrated under reduced pressure to obtain the target (823 mg, 91%).

Aufarbeitung

  1. filtrationThe reaction solution was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. temperaturecooled conditions
  4. filtrationAfter filtration
  5. concentrationthe filtrate was concentrated under reduced pressure
  6. customto obtain the target (823 mg, 91%)

Quellen und Nachweise

ORD-Eintrag
ord-c1ce6b42785d42099d6a673f19ba5e8e
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367698B2

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